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You can use a Tweet Search in your bot's Twitter properties to process and reply or retweet tweets. The Tweet Search uses Twitter's search API which has many options such as from:user to filter tweets. See, https://dev.twitter.com/rest/public/search Replying to all tweets for an account may be considered spam will most likely result in having your bot suspended. It is possible to reply to tweets that contain a set of keywords, http://www.botlibre.com/forum-post?id=25560 You can also retweet tweets that contain a set of keywords, http://www.botlibre.com/forum-post?id=13218